Estrogen (ESR1) and Progesterone (PRG) Receptor Genes in Benign Mammary Dysplasia in Women of Reproductive Age with Endometrial Hyperplasia

Study Objective: To identify the role of estrogen (ESR1) and progesterone (PRG) receptor genes in benign mammary dysplasia (BMD) women reproductive age with endometrial hyperplasia (EH). Design: prospective controlled cohort study. Materials Methods. We examined 105 aged 18 to 49 years old who were divided into three groups: group I — 36 BMD patients; II 27 EH without atypia; III 42 patients atypia. Patients disorders subgroups diffuse nodal BMD. studied polymorphism ratio their isoforms blood serum. ESR1 PRG gene was analysed using polymerase chain reaction fluorescent genotyping detection TaqMan probes. Results. In PvuII C/T there significant differences between СС allele (p = 0.014), but not study groups. Analysis rate Xbal A/G alleles revealed GG 0.015), while no The Val660Leu +331G/A statistically groups; also, Conclusion. Combined hyperplastic processes endometrium glands depend on specificity system progesteron genes. Associations various combinations susceptibility demonstrate presence for each clinical pathogenic variant (diffuse or local forms). Keywords: dysplasia; hyperplasia; receptors; ESR1,